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Related Concept Videos

What is the Cell Cycle?00:56

What is the Cell Cycle?

The cell cycle refers to the sequence of events occurring throughout a typical cell’s life. In eukaryotic cells, the somatic cell cycle has two stages: the interphase and the mitotic phase. During interphase, the cell grows, performs its basic metabolic functions, copies its DNA, and prepares for mitotic cell division. Then, during mitosis and cytokinesis, the cell divides its nuclear and cytoplasmic materials, respectively. This generates two daughter cells that are identical to the original...
What is the Cell Cycle?01:04

What is the Cell Cycle?

The cell cycle refers to the sequence of events occurring throughout a typical cell’s life. In eukaryotic cells, the somatic cell cycle has two stages: interphase and the mitotic phase. During interphase, the cell grows, performs its basic metabolic functions, copies its DNA, and prepares for mitotic cell division. Then, during mitosis and cytokinesis, the cell divides its nuclear and cytoplasmic materials, respectively. This generates two daughter cells that are identical to the original...
What is the Cell Cycle?00:56

What is the Cell Cycle?

The cell cycle refers to the sequence of events occurring throughout a typical cell’s life. In eukaryotic cells, the somatic cell cycle has two stages: the interphase and the mitotic phase. During interphase, the cell grows, performs its basic metabolic functions, copies its DNA, and prepares for mitotic cell division. Then, during mitosis and cytokinesis, the cell divides its nuclear and cytoplasmic materials, respectively. This generates two daughter cells that are identical to the original...
What is the Cell Cycle?01:04

What is the Cell Cycle?

The cell cycle refers to the sequence of events occurring throughout a typical cell’s life. In eukaryotic cells, the somatic cell cycle has two stages: interphase and the mitotic phase. During interphase, the cell grows, performs its basic metabolic functions, copies its DNA, and prepares for mitotic cell division. Then, during mitosis and cytokinesis, the cell divides its nuclear and cytoplasmic materials, respectively. This generates two daughter cells that are identical to the original...
The Cell Cycle Control System01:28

The Cell Cycle Control System

The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and function at the cell...
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...

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Temporal Tracking of Cell Cycle Progression Using Flow Cytometry without the Need for Synchronization
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Temporal Tracking of Cell Cycle Progression Using Flow Cytometry without the Need for Synchronization

Published on: August 16, 2015

When cell cycle meets development.

Philipp Kaldis1, Helena E Richardson

  • 1Institute of Molecular and Cell Biology (IMCB), 61 Biopolis Drive, Proteos, Singapore 138673, Singapore. kaldis@imcb.a-star.edu.sg

Development (Cambridge, England)
|December 2, 2011
PubMed
Summary
This summary is machine-generated.

Researchers explored cell proliferation and differentiation in metazoans. The workshop highlighted new insights into how regulators control these processes during development, offering a unified view across diverse species.

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Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis
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Measuring Cell Cycle Progression Kinetics with Metabolic Labeling and Flow Cytometry

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Area of Science:

  • Developmental Biology
  • Cell Biology
  • Genetics

Background:

  • Understanding the control of cell proliferation and differentiation is fundamental to developmental biology.
  • Metazoan development involves complex regulatory networks governing cell fate and tissue formation.

Purpose of the Study:

  • To review common themes from a workshop on developmental control.
  • To highlight novel insights into the interplay between regulators of cell proliferation and differentiation.

Main Methods:

  • Synthesis of information presented at the 'Growth, Division and Differentiation: Understanding Developmental Control' workshop.
  • Review of research findings on cell proliferation and differentiation across various metazoans.

Main Results:

  • Identified common themes in developmental control across species like flies and mice.
  • Highlighted novel insights into the regulatory mechanisms governing cell proliferation and differentiation.

Conclusions:

  • The interplay between regulators of cell proliferation and differentiation is crucial for metazoan development.
  • Further research is needed to fully elucidate these complex regulatory networks.