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Exercise modulates circulating adipokine levels in hypertrophic cardiomyopathy
Paweł Petkow Dimitrow1, Anetta Undas, Tsung O Cheng
1Institute of Cardiology, Jagiellonian University, Medical College, Kraków, Poland. dimitrow@mp.pl
Polskie Archiwum Medycyny Wewnetrznej
|December 2, 2011
Summary
In hypertrophic cardiomyopathy (HCM) patients, exercise increased adiponectin and decreased leptin levels, unlike in healthy individuals. These adipokine changes were independent of the left ventricular outflow tract (LVOT) gradient.
Area of Science:
- Cardiology
- Endocrinology
- Exercise Physiology
Background:
- Previous studies indicated elevated adiponectin in left ventricular hypertrophy patients at rest.
- Limited research explored adipokine dynamics during exercise in hypertrophic cardiomyopathy (HCM).
Purpose of the Study:
- To compare adiponectin, resistin, and leptin levels in HCM patients versus controls, at rest and post-exercise.
- To investigate correlations between adipokine levels and the left ventricular outflow tract (LVOT) gradient during rest and exercise.
Main Methods:
- Studied 29 HCM patients and 19 healthy controls, matched for age, sex, and BMI.
- Measured adiponectin, resistin, and leptin at rest and peak exercise via treadmill test with continuous echocardiography.
- Monitored left ventricular outflow tract (LVOT) gradient throughout the exercise test.
Main Results:
- HCM patients showed higher resting resistin and leptin levels compared to controls.
- Exercise increased adiponectin and decreased leptin in HCM patients (P <0.05).
- Adipokine levels did not correlate with resting or peak exercise LVOT gradient in HCM patients.
Conclusions:
- Moderate exercise alters adiponectin and leptin levels in HCM patients, independent of LVOT gradient changes.
- The potential cardioprotective role of adiponectin during exercise stress in HCM warrants further investigation.
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