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Relationship between mean platelet volume and left ventricular systolic function in patients with metabolic syndrome

Huseyin U Yazici1, Fatih Poyraz, Nihat Sen

  • 1Department of Cardiology, Gazi University School of Medicine, Ankara, Turkey. drhyazici@gmail.com

Clinical and Investigative Medicine. Medecine Clinique Et Experimentale
|December 2, 2011
PubMed

Insights

In patients with metabolic syndrome and first ST-elevation myocardial infarction, higher mean platelet volume (MPV) indicates worse left ventricular systolic function. MPV may serve as a prognostic marker for these patients.

Area of Science:

  • Cardiology
  • Hematology
  • Metabolic Disorders

Background:

  • Mean platelet volume (MPV) reflects platelet activation, a key factor in coronary heart disease pathophysiology.
  • Metabolic syndrome (MS) can impair left ventricular systolic function through thrombotic events and inflammation during acute myocardial infarction.

Purpose of the Study:

  • To investigate the association between MPV and left ventricular systolic function.
  • Focus on patients experiencing their first ST-elevation myocardial infarction (STEMI) with metabolic syndrome.

Main Methods:

  • MPV was measured upon admission in 71 patients (33 preserved, 48 depressed left ventricular systolic function).
  • Patients with metabolic syndrome and first STEMI were categorized based on ejection fraction (≤50% for depressed function).
  • MPV levels were compared between groups with preserved and depressed left ventricular systolic function.

Main Results:

  • MPV levels were significantly higher in patients with depressed left ventricular systolic function (p=0.02).
  • Logistic regression revealed an independent association between MPV and worsened left ventricular systolic function (OR 1.08, 95% CI: 1.04-1.20, p=0.02).

Conclusions:

  • Elevated admission MPV correlates with the severity of left ventricular systolic depression in metabolic syndrome patients post-STEMI.
  • MPV shows potential as a valuable prognostic indicator for individuals with metabolic syndrome and ST-elevation myocardial infarction.
Abstract

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