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Updated: May 27, 2026
07:09
Isolation of Adipose Tissue Immune Cells
Published on: May 22, 2013
[Adipose tissue, a new playground for immune cells]
Elise Dalmas1, Joan Tordjman, Michèle Guerre-Millo
1Université Pierre et Marie Curie-Paris 6, Centre de recherche des Cordeliers, F-75006 Paris, France.
Medecine Sciences : M/S
|December 2, 2011
Summary
Obesity causes low-grade inflammation in adipose tissue, attracting macrophages. These macrophages have diverse roles, potentially impacting inflammation, metabolism, and fibrosis, offering new therapeutic targets.
Area of Science:
- Immunology
- Metabolic Diseases
- Adipose Tissue Biology
Context:
- Obesity is characterized by chronic low-grade inflammation in adipose tissue.
- Adipose tissue macrophages (ATMs) play a crucial role in this inflammatory process.
- Understanding ATM function is key to addressing obesity-related complications.
Purpose:
- To review the mechanisms of macrophage accumulation in obese adipose tissue.
- To explore the diverse phenotypes and functions of ATMs in obesity.
- To discuss the link between ATMs, inflammation, metabolism, and fibrosis.
Summary:
- This review examines how monocytes are recruited to adipose tissue and how macrophages adapt their phenotype in obesity.
- It highlights the dual role of ATMs in promoting inflammation and metabolic dysfunction, yet also potentially maintaining adipose tissue homeostasis.
- The emerging role of ATMs in adipose tissue fibrosis is also considered.
Impact:
- Provides insights into the complex biology of adipose tissue inflammation in obesity.
- Identifies adipose tissue macrophages as key players in metabolic alterations and fibrosis.
- Suggests potential avenues for novel therapeutic strategies targeting adipose tissue inflammation and its consequences.
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