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Embryo banking between induction and consolidation chemotherapy in women with leukemia
Brooke V Rossi1, Rachel K Ashby, Serene S Srouji
1Department of Obstetrics, Gynecology, and Reproductive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. brooke.rossi@uhhospitals.org
Objective:
To report the results of controlled ovarian hyperstimulation (COH) after long-acting GnRH agonist (GnRH-a) and chemotherapy for the purposes of embryo cryopreservation.
Design:
Case report.
Setting:
University medical center.
Patient(S):
Two premenopausal women with acute myelogenous leukemia with recent treatment with GnRH-a and induction chemotherapy for hematopoietic cell transplantation (HCT).
Intervention(S):
COH with embryo cryopreservation.
Main Outcome Measure(S):
Numbers of oocytes and embryos cryopreserved.
Result(S):
Both patients responded to gonadotropin stimulation and cryopreserved embryos.
Conclusion(S):
Women who have received recent long-acting GnRH-a and chemotherapy may respond to gonadotropin stimulation. The option of embryo banking can be offered to leukemia patients who are preparing for HCT.
