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Impact of peritonitis on long-term survival of peritoneal dialysis patients

E Muñoz de Bustillo1, F Borrás, C Gómez-Roldán

  • 1Nephrology Department, Marina Baixa Hospital, Avda. En Jaume Botella Major 7, Villajoyosa, Alicante, Spain. emunozd@senefro.org

Nefrologia : Publicacion Oficial De La Sociedad Espanola Nefrologia
|December 2, 2011
PubMed

Insights

Peritonitis episodes significantly increase mortality risk and technique failure in peritoneal dialysis (PD) patients. Each peritonitis event, especially those requiring hospitalization, negatively impacts long-term survival.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Epidemiology

Background:

  • Peritonitis is a common complication in peritoneal dialysis (PD).
  • The cumulative impact of peritonitis episodes on PD patient outcomes remains incompletely understood.

Purpose of the Study:

  • To quantify the risk associated with each peritonitis episode on patient survival.
  • To assess the impact of peritonitis on the long-term success of PD technique.

Main Methods:

  • Retrospective analysis of 1515 patients from the Levante registry (1993-2005).
  • Utilized Cox regression for time-dependent variables to analyze 1609 peritonitis episodes.
  • Investigated associations between peritonitis, mortality, and technique failure.

Main Results:

  • Each peritonitis episode increased mortality risk (HR 2.01), with higher risk for hospitalized cases.
  • Mortality risk escalated with successive peritonitis episodes.
  • Peritonitis was the sole independent predictor of PD technique failure (HR 1.29).
  • Specific bacterial and fungal pathogens presented differential risks for mortality and technique failure.

Conclusions:

  • Peritonitis episodes demonstrably reduce long-term survival in PD patients.
  • Peritonitis is a critical factor influencing the longevity of PD treatment.
Abstract

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