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Palmaenones A and B, two new antimicrobial chlorinated cyclopentenones from discomycete Lachnum palmae
Takunori Matsumoto1, Tsuyoshi Hosoya, Hiroshi Tomoda
1Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki 305–8572, Japan.
Abstract:
Two new antimicrobial chlorinated cyclopentenones, palmaenones A (1) and B (2) were isolated from the culture broth of discomycete Lachnum palmae (NBRC-106495), and the structures of 1 and 2 were elucidated by spectroscopic data and the stereochemistry of 1 was directly determined by a single-crystal X-ray diffraction analysis. Palmaenones A (1) and B (2) are cyclopentenones containing three chlorines. Compound 1 exhibited potent antimicrobial activity against Micrococcus luteus, Mycobacterium smegmatis, Escherichia coli, Xanthomonas campestris, and Mucor racemosus, while the activities of compound 2 were weaker than 1.
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