Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 27, 2026

Non-invasive Skeletal Muscle Quantification in Small Animals Using Micro-computed Tomography
07:33

Non-invasive Skeletal Muscle Quantification in Small Animals Using Micro-computed Tomography

Published on: November 8, 2024

Histomorphometry in rodents.

Reinhold G Erben1, Martin Glösmann

  • 1Institute of Physiology, Pathophysiology, and Biophysics, Department of Biomedical Sciences, University of Veterinary Medicine, Vienna, Austria. Reinhold.Erben@vetmeduni.ac.at

Methods in Molecular Biology (Clifton, N.J.)
|December 2, 2011
PubMed
Summary

Bone histomorphometry is crucial for understanding bone disease and treatment mechanisms. This review details rodent bone sectioning, staining, and analysis methods for accurate study.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of high-dose methotrexate on bone metabolism: A narrative literature review.

Bone reports·2026
Same author

Establishment and characterization of a human juvenile bone marrow-derived mesenchymal stem/stromal cell line under advanced culture conditions for osteogenic differentiation.

Frontiers in bioengineering and biotechnology·2026
Same author

Dietary potassium restriction causes hypercalciuria, hypocalcemia, and bone loss in male mice.

JCI insight·2026
Same author

Heart Failure but Not Myocardial Infarction Is Causing Bone Loss in Rodent Models in an FGF23-Independent Manner.

International journal of molecular sciences·2026
Same author

Deletion of cardiac fibroblast growth factor-23 beneficially impacts myocardial energy metabolism in left ventricular hypertrophy.

npj metabolic health and disease·2025
Same author

Fibroblast growth factor 23 and fibroblast growth factor receptor 4 promote cardiac metabolic remodeling in chronic kidney disease.

Kidney international·2025

Area of Science:

  • Orthopedics
  • Histology
  • Biomedical Research

Background:

  • Bone histomorphometry is essential for studying bone disease pathophysiology.
  • It elucidates the cellular mechanisms of therapeutic interventions.
  • Rodent models are frequently used in bone research.

Purpose of the Study:

  • To provide a comprehensive review of bone histomorphometry techniques.
  • To outline methods for processing and analyzing rodent bone sections.
  • To serve as a guide for researchers in the field.

Main Methods:

  • Review of established protocols for bone embedding and sectioning.
  • Discussion of various staining techniques for bone tissue.
  • Overview of quantitative analysis methods for bone histomorphometry.

Main Results:

  • Detailed description of each step in the bone histomorphometry workflow.
  • Highlighting critical parameters for successful tissue processing and analysis.
  • Emphasis on reproducibility and accuracy in rodent bone studies.

Conclusions:

  • Standardized methods in bone histomorphometry are vital for reliable research.
  • This review offers practical guidance for implementing these techniques.
  • Accurate analysis of bone sections aids in understanding skeletal diseases and treatments.

More Related Videos

A System for Tracking the Dynamics of Social Preference Behavior in Small Rodents
08:38

A System for Tracking the Dynamics of Social Preference Behavior in Small Rodents

Published on: November 21, 2019

Echocardiographic and Histological Examination of Cardiac Morphology in the Mouse
10:22

Echocardiographic and Histological Examination of Cardiac Morphology in the Mouse

Published on: October 26, 2017

Related Experiment Videos

Last Updated: May 27, 2026

Non-invasive Skeletal Muscle Quantification in Small Animals Using Micro-computed Tomography
07:33

Non-invasive Skeletal Muscle Quantification in Small Animals Using Micro-computed Tomography

Published on: November 8, 2024

A System for Tracking the Dynamics of Social Preference Behavior in Small Rodents
08:38

A System for Tracking the Dynamics of Social Preference Behavior in Small Rodents

Published on: November 21, 2019

Echocardiographic and Histological Examination of Cardiac Morphology in the Mouse
10:22

Echocardiographic and Histological Examination of Cardiac Morphology in the Mouse

Published on: October 26, 2017