Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Decrease in serum receptor-reactive somatomedin in diabetes.

R C Baxter, A S Brown, J R Turtle

    Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
    |March 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Correction to: Elevated maternal C-reactive protein and autism in a national birth cohort.

    Molecular psychiatry·2025
    Same author

    Patient-centred outcomes.

    BJA education·2025
    Same author

    Infectious and immunogenetic factors in bipolar disorder.

    Acta psychiatrica Scandinavica·2017
    Same author

    Insights into the effects of metal nanostructuring and oxidation on the work function and charge transfer of metal/graphene hybrids.

    Nanoscale·2015
    Same author

    Development of on-line FTIR spectroscopy for siloxane detection in biogas to enhance carbon contactor management.

    Talanta·2015
    Same author

    CD8 subunit expression by plasmacytoid dendritic cells is variable, and does not define stable subsets.

    Mucosal immunology·2013
    Same journal

    Inflammatory Profile of Lipedema: A Comparative Evaluation with Obese and Normal-weight Women.

    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·2026
    Same journal

    Comparative Effects of Experimental Diabetes Mellitus and Glucocorticoid-Induced Hypercortisolemia on Pancreatic and Adrenal Endocrine Architecture: A Pathological Study in Rats.

    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·2026
    Same journal

    Psychiatric Symptoms in Women with Mild Autonomous Cortisol Secretion Versus Non-Functioning Adrenal Adenomas: A Cross-Sectional Study.

    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·2026
    Same journal

    Antisemitism as a Chronic Cardiometabolic, Endocrine, and Glutamatergic Stressor Requiring Psychometric Monitoring.

    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·2026
    Same journal

    Severe Acute Respiratory Syndrome Coronavirus-2 Infection and New Changes in Thyroid Function Parameters during Hospitalization and Follow-up.

    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·2026
    Same journal

    Maternal Serum Epidermal Growth Factor Levels at 37 Weeks of Gestation in Late-Term Pregnancies.

    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·2026
    See all related articles

    Diabetes in rats significantly lowers somatomedin (SM) levels, particularly high molecular weight activity. This suggests insulin plays a crucial role in maintaining serum somatomedin levels.

    Area of Science:

    • Endocrinology
    • Metabolic Research
    • Biochemistry

    Background:

    • Somatomedin (SM) is a key growth factor regulated by various physiological conditions.
    • Diabetes mellitus is known to affect numerous hormonal and metabolic pathways.
    • Understanding SM regulation in diabetes is crucial for metabolic research.

    Purpose of the Study:

    • To quantify receptor-reactive somatomedin (SM) levels in diabetic rats.
    • To investigate the characteristics of SM in diabetic versus control rat serum.
    • To explore the relationship between diabetes, SM, and SM binding protein.

    Main Methods:

    • Radioreceptor assay using 125I-labelled human somatomedin and human placental membrane.
    • Streptozotocin-induced diabetes model in rats of varying ages.

    Related Experiment Videos

  • Gel chromatography to analyze molecular weight fractions of serum SM.

    • Main Results:

    • Diabetic rats showed up to a 75% decrease in receptor-reactive somatomedin levels.
    • The decrease in SM correlated with increasing serum glucose levels.
    • Reduced SM in diabetes was attributed to a loss of high molecular weight SM activity, not altered binding protein levels.

    Conclusions:

    • Insulin appears to play a significant role in maintaining serum somatomedin levels.
    • Diabetes-induced changes in SM are primarily linked to alterations in high molecular weight SM fractions.
    • Further research is warranted to elucidate the precise mechanisms of insulin's influence on SM regulation.