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Related Experiment Videos

Intracarotid hydroxyethyl methacrylate solution causing stroke in dogs.

P Purdy1, C L White, H Batjer

  • 1Department of Radiology, University of Texas Southwestern Medical Center, Dallas.

Journal of Neurosurgery
|November 1, 1990
PubMed
Summary
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Unpolymerized hydroxyethyl methacrylate (HEMA) injected into the carotid artery caused cerebral infarctions in dogs, highlighting potential risks of this polymerizing solution in interventional neuroradiology.

Area of Science:

  • Interventional Neuroradiology
  • Vascular Neurology
  • Biomaterials Science

Background:

  • Hydroxyethyl methacrylate (HEMA) is used as a polymerizing solution for detachable balloons in interventional neuroradiology.
  • The potential risks of accidental release of unpolymerized HEMA into the carotid artery are not well-documented.

Purpose of the Study:

  • To investigate the toxicological effects of intravascular hydroxyethyl methacrylate (HEMA) injection in a canine model.
  • To assess the safety of HEMA in the context of potential accidental release during interventional neuroradiology procedures.

Main Methods:

  • Seven mongrel dogs underwent transfemoral catheterization and common carotid artery injection of HEMA solution (1-4 cc).
  • Angiography was performed to assess immediate vascular effects.

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  • Histopathological examination of brain tissue was conducted on surviving animals at 48 hours.

    • Main Results:

    • Angiography showed intravascular thrombosis and possible spasm following HEMA injection.
    • Five out of seven dogs developed histopathologically confirmed cerebral infarctions.
    • Higher HEMA volumes (2-4 cc) were associated with mortality within 48 hours.
    • No evidence of intravascular polymerization was observed.

    Conclusions:

    • Accidental intravascular release of unpolymerized HEMA can lead to significant cerebral infarction.
    • The use of HEMA in detachable balloons warrants further investigation into its toxicology and physical properties.
    • Clinical use of HEMA in interventional neuroradiology requires careful consideration of potential risks.