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Adults with attention-deficit/hyperactivity disorder - a brain magnetic resonance spectroscopy study
Margaretha Dramsdahl1, Lars Ersland, Kerstin J Plessen
1Division of Psychiatry, Haukeland University Hospital Bergen, Norway.
Background:
Impaired cognitive control in individuals with attention-deficit/hyperactivity disorder (ADHD) may be related to a prefrontal cortical glutamatergic deficit. We assessed the glutamate level in the left and the right midfrontal region including the anterior cingulate cortex in adults with ADHD and healthy controls.
Methods:
Twenty-nine adults with ADHD and 38 healthy controls were included. We used Proton Magnetic Resonance Imaging with single voxel point-resolved spectroscopy to measure the ratio of glutamate to creatine (Glu/Cre) in the left and the right midfrontal region in the two groups.
Results:
The ADHD group showed a significant reduction of Glu/Cre in the left midfrontal region compared to the controls.
Conclusion:
The reduction of Glu/Cre in the left midfrontal region in the ADHD group may reflect a glutamatergic deficit in prefrontal neuronal circuitry in adults with ADHD, resulting in problems with cognitive control.
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