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Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
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Published on: April 26, 2017

Splicing programs and cancer

Sophie Germann1, Lise Gratadou, Martin Dutertre

  • 1Université de Lyon, 28 rue Laënnec, 69008 Lyon, France.

Journal of Nucleic Acids
|December 2, 2011
PubMed

Insights

Alternative splicing alterations are increasingly recognized in cancer. Large-scale analyses reveal these changes impact key cellular networks, offering new therapeutic targets for cancer initiation and progression.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Gene-by-gene analysis has identified splicing alterations in various cancers.
  • Novel technologies enable large-scale analysis of alternative splicing in cancer.

Purpose of the Study:

  • To explore the role of alternative splicing in cancer at a large scale.
  • To understand how splicing alterations contribute to cancer initiation and progression.
  • To identify splicing factors regulating cancer-associated splicing programs.

Main Methods:

  • Genome-wide analyses of alternative splicing.
  • Identification of misregulated splicing variants in cancer.
  • Studies on splicing factors controlling cancer-associated splicing programs.

Main Results:

  • Alternative splicing alterations affect gene networks crucial for cellular programs.
  • Many cancer-associated splicing variants are also present in normal tissues.
  • Splicing factors have been identified that control cancer-associated splicing programs.

Conclusions:

  • Splicing programs are altered during cancer initiation and progression.
  • Characterizing splicing programs and their regulation is key to understanding cancer genetics.
  • Splicing factors and programs represent potential therapeutic targets for cancer treatment.

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