Related Experiment Video
Updated: May 27, 2026

The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well
Published on: February 27, 2026
[Thrombin generation test at physiological and risk gravidity]
V Lattová1, M Procházka, J Ulehlová
1Porodnicko-gynekologická klinika FN, Olomouc.
Unlabelled:
Generation of thrombin is pivotal step of hemostasis, according to in vitro experiments, thrombin generation occurs in 2 phases. Initially small amount of thrombin is produced after activation of factor X by complex TF/FVIIa. Thrombin multiplies coagulation by activation of platelets, F V a F VIII. Complex of TF/FVIIa activates also F VIII a, F IX, F VIII and FIXa and its binding to surface of platelets, which activates F X and products quantity of thrombin and leads formation of fibrin and finaly to triggering clotting.
Design:
Review.
Setting:
Department of Obstetrics and Gynecology, University Hospital Olomouc.
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