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Isolation and structure elucidation of two new cytotoxic metabolites from red yeast rice
Ines Ferse1, Marina Langlitz, Karin Kleigrewe
1Institute of Food Chemistry, Westfälische Wilhelms-Universität, Corrensstrasse 45, D-48149 Münster, Germany.
Abstract:
In this study, 10 already described secondary metabolites and 2 unknown metabolites were identified in an extract of Monascus purpureus by high-performance liquid chromatography-diode array detection. The unknown metabolites were isolated and their chemical structures were elucidated. The new metabolites possess the molecular formulas C(21)H(27)NO(4) and C(23)H(31)NO(4). They were named monascopyridines E and F due to their pyridine backbone. The cytotoxicity of the new compounds was studied using immortalised human kidney epithelial cells displaying IC(50) values in the micromolar range.