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Related Experiment Video

Updated: May 27, 2026

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

Primary orbital extraskeletal osteosarcoma.

Jennifer C Fan¹, Duncan L Lamont, Adam R Greenbaum

¹Department of Ophthalmology, Waikato Hospital, Waikato District Health Board, Hamilton, New Zealand.

Orbit (Amsterdam, Netherlands)

|December 3, 2011

Summary

This summary is machine-generated.

A rare orbital extraskeletal osteosarcoma (ESOS) case is presented in an elderly male. Potential risk factors included immunosuppression and radiotherapy, highlighting the rarity of this soft tissue tumor in the orbit.

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Area of Science:

Oncology
Ophthalmology
Pathology

Background:

Extraskeletal osteosarcoma (ESOS) is a rare malignant soft tissue tumor producing osteoid, accounting for <5% of all osteosarcomas.
ESOS primarily affects individuals over 50 and is associated with a poor prognosis.
Primary ESOS of the orbit is exceptionally uncommon.

Observation:

A 78-year-old male with rheumatoid arthritis on corticosteroids developed a rapidly growing, calcified mass in the left medial canthus and orbit post-basal cell carcinoma treatment.
Incisional biopsy revealed atypical cells with mitotic activity and rosette formation.
Surgical intervention included orbital exenteration and partial maxillectomy.

Findings:

Histopathological examination confirmed the diagnosis of extraskeletal osteosarcoma.
The tumor was found to involve the orbital soft tissues without continuity to bone or periosteum.

Implications:

This case underscores the possibility of ESOS developing in the orbit, potentially influenced by factors like long-term corticosteroid use and adjuvant radiotherapy.
Highlights the importance of considering rare diagnoses in orbital masses, especially in immunocompromised patients or those with a history of radiation.
Further research may be needed to understand the specific predisposing factors and optimal management strategies for orbital ESOS.