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Related Experiment Video

Updated: May 27, 2026

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

Comorbidities in patients with gout.

Naomi Ichikawa¹, Atsuo Taniguchi, Wako Urano

¹Institute of Rheumatology, Tokyo Women's Medical University, Shinjuku-ku, Tokyo, Japan. naomi@ior.twmu.ac.jp

Nucleosides, Nucleotides & Nucleic Acids

|December 3, 2011

Summary

Gout patients with tophi or comorbidities often have longer disease duration and higher serum uric acid (SUA) levels. Sustained hyperuricemia is linked to gout complications like renal impairment and hypertension.

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Last Updated: May 27, 2026

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

Area of Science:

Nephrology
Rheumatology
Internal Medicine

Background:

Gout, a common disease linked to hyperuricemia, presents with acute flares and can lead to tophi and comorbidities.
Associated conditions include obesity, hypertension, lipid disorders, renal dysfunction, and urolithiasis.
Understanding the relationship between gout characteristics and these complications is crucial for patient management.

Purpose of the Study:

To examine the associations between gouty tophi, comorbidities, and patient demographic/disease characteristics.
To investigate the link between gout duration, serum uric acid levels, and the presence of tophi and comorbidities.

Main Methods:

Retrospective analysis of 422 male gout patients' records from an outpatient clinic.
Collected demographic and laboratory data at the initial visit.
Utilized multiple regression models to analyze relationships between comorbidities and patient characteristics.

Main Results:

Tophi presence correlated significantly with longer gout duration and higher maximum serum uric acid (SUA).
Reduced estimated glomerular filtration rate (eGFR) associated with older age of onset, longer gout duration, and higher maximum SUA.
Increased hypertension frequency linked to longer gout duration, suggesting poor gout control contributes to hypertension.

Conclusions:

Tophi formation and renal impairment in gout are closely related to sustained hyperuricemia and disease duration.
Hypertension in gout patients may be exacerbated by prolonged disease duration and inadequate gout management.
Findings offer valuable insights for optimizing gout management strategies and patient education.