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Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...

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Methodology for Sputum Induction and Laboratory Processing
13:28

Methodology for Sputum Induction and Laboratory Processing

Published on: December 17, 2017

Asthma exacerbations: origin, effect, and prevention.

David J Jackson1, Annemarie Sykes, Patrick Mallia

  • 1National Heart and Lung Institute, Imperial College London, London, United Kingdom.

The Journal of Allergy and Clinical Immunology
|December 3, 2011
PubMed
Summary
This summary is machine-generated.

Asthma exacerbations, often triggered by viruses, cause significant health and economic burdens. Understanding these triggers and their interactions is key to developing better prevention and treatment strategies for this common respiratory disease.

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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
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Published on: November 4, 2010

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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Area of Science:

  • Pulmonology
  • Immunology
  • Epidemiology

Background:

  • Asthma is a prevalent chronic respiratory disease impacting millions globally, with acute exacerbations posing significant morbidity and healthcare costs.
  • Despite advancements, acute asthma exacerbations remain common, particularly in children, imposing a substantial burden on patients and healthcare systems.
  • Respiratory viral infections are primary triggers for asthma exacerbations, yet the underlying mechanisms and potential interactions with other triggers are not fully understood.

Purpose of the Study:

  • To provide a comprehensive overview of the health, economic, and social burden associated with asthma exacerbations.
  • To review the pathogenesis of asthma exacerbations, focusing on identified triggers and their complex interactions.
  • To discuss current preventative measures and emerging treatments for mitigating the impact of asthma exacerbations.

Main Methods:

  • Literature review and synthesis of existing research on asthma exacerbations.
  • Analysis of epidemiological data concerning asthma prevalence and exacerbation triggers.
  • Examination of current and developmental therapeutic strategies for asthma exacerbation management.

Main Results:

  • Asthma exacerbations represent a major global health challenge with substantial economic and social implications.
  • Viral infections are key triggers, and their interactions with other factors can increase exacerbation risk.
  • Existing preventative strategies and novel treatments under development offer potential to reduce exacerbation burden.

Conclusions:

  • A deeper understanding of asthma exacerbation mechanisms, particularly viral triggers and their interactions, is crucial.
  • Effective management requires a multi-faceted approach including prevention and the development of new therapies.
  • Addressing the burden of asthma exacerbations necessitates continued research into pathogenesis and treatment innovation.