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Updated: May 27, 2026
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Longitudinal Morphological and Physiological Monitoring of Three-dimensional Tumor Spheroids Using Optical Coherence Tomography
Published on: February 9, 2019
Optical coherence tomography for rapid tissue screening and directed histological sectioning.
Woonggyu Jung1, Stephen A Boppart
1Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, USA.
Analytical Cellular Pathology (Amsterdam)
|December 3, 2011
Summary
Optical coherence tomography (OCT) offers real-time, high-resolution tissue imaging, addressing limitations of traditional histology. This advanced technique aids in fast screening and targeted tissue sectioning for improved pathology diagnostics.
Area of Science:
- Medical Imaging
- Pathology
- Biomedical Engineering
Background:
- Histological examination is the gold standard in pathology but has limitations.
- Current drawbacks include lack of real-time in vivo observation and potential sampling errors.
- There is a need for complementary or alternative imaging techniques for rapid, non-destructive tissue screening.
Purpose of the Study:
- To review the application of Optical Coherence Tomography (OCT) in pathology.
- To highlight OCT's potential as an image guidance tool for tissue screening.
- To explore OCT's role in directed histological tissue sectioning.
Main Methods:
- Review of existing literature on OCT in pathology.
- Description of OCT's capabilities for real-time, high-resolution cross-sectional imaging.
- Discussion of OCT as an adjunct to traditional histological methods.
Main Results:
- OCT provides high-resolution imaging comparable to histology.
- OCT enables real-time, in vivo observation, overcoming a key limitation of histology.
- OCT facilitates rapid tissue screening and can guide targeted biopsies.
Conclusions:
- OCT is a promising imaging modality for pathology.
- OCT can serve as an effective adjunct to histology, especially when rapid screening or large area investigation is needed.
- OCT enhances diagnostic accuracy and efficiency by guiding histological sectioning.
