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Related Experiment Video

Updated: May 27, 2026

Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model
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Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model

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Primary pancreatic lymphoma: a population-based analysis using the SEER program.

Mark V Mishra1, Scott W Keith, Xinglei Shen

  • 1Department of Radiation Oncology, Kimmel Cancer Center, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA. mark.mishra@jeffersonhospital.org

American Journal of Clinical Oncology
|December 3, 2011
PubMed
Summary
This summary is machine-generated.

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Primary pancreatic lymphoma (PPL) is rare, but this study of 523 cases found age over 60, other race, and single/widowed status predict worse outcomes for PPL patients.

Area of Science:

  • Oncology
  • Hematology
  • Epidemiology

Background:

  • Primary pancreatic lymphoma (PPL) is a rare malignancy, comprising only 0.5% of pancreatic masses.
  • Limited data exists on PPL epidemiology and patient outcomes.
  • This study analyzes a large cohort of 523 PPL cases from the Surveillance, Epidemiology, and End Results (SEER) database.

Purpose of the Study:

  • To investigate the epidemiology of primary pancreatic lymphoma.
  • To identify prognostic factors influencing survival in PPL patients.
  • To describe treatment patterns and outcomes for PPL.

Main Methods:

  • Retrospective analysis of 523 PPL cases diagnosed between 1973 and 2007.
  • Extraction of patient demographics, tumor characteristics, and treatment data.

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Published on: April 18, 2025

  • Kaplan-Meier survival analysis and Cox proportional hazards modeling for prognostic factor identification.

    • Main Results:

    • The cohort was 58% male, with a median age of 65-69 years at diagnosis.
    • Diffuse large B-cell lymphoma was the most common subtype (56%).
    • Five-year overall survival was 45%; advanced age (>60), non-white race, and single/widowed status were associated with increased mortality.

    Conclusions:

    • This study represents the largest published series on PPL.
    • Age over 60, female sex, and married status were identified as independent prognostic factors for decreased all-cause mortality.