Related Experiment Video
Updated: May 27, 2026
07:27
Anterior Segment Organ Culture Platform for Tracking Open Globe Injuries and Therapeutic Performance
Published on: August 25, 2021
Endophthalmitis following open-globe injuries.
Y Ahmed1, A M Schimel, A Pathengay
1Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine, Miami, FL 33136, USA.
Eye (London, England)
|December 3, 2011
Summary
Early wound closure and prompt antibiotics reduce traumatic endophthalmitis. Key risk factors include foreign bodies and delayed treatment, necessitating early recognition and intravitreal antibiotic therapy for better visual outcomes.
Area of Science:
- Ophthalmology
- Infectious Diseases
Background:
- Traumatic endophthalmitis is a severe complication of open-globe injuries.
- Incidence may be decreasing due to improved management strategies.
Purpose of the Study:
- To review risk factors, microbiology, clinical signs, and treatment of traumatic endophthalmitis.
- To emphasize the importance of early intervention for visual acuity outcomes.
Main Methods:
- Review of literature on traumatic endophthalmitis.
- Discussion of risk factors, microbiology, clinical presentation, and treatment protocols.
Main Results:
- Risk factors include retained intraocular foreign body, rural injury setting, lens disruption, and delayed wound closure.
- Common pathogens include virulent organisms like Bacillus species.
- Early signs include pain, hypopyon, vitritis, and retinal periphlebitis.
Conclusions:
- Prompt wound closure and prophylactic antibiotics are crucial for preventing endophthalmitis.
- Early diagnosis and treatment with intravitreal antibiotics (vancomycin, ceftazidime) improve visual outcomes.
- Management of concurrent retinal detachment involves vitrectomy and antibiotics.
Related Concept Videos
01:25Glaucoma: Overview
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
01:22Microbiome of the Eye
The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...
01:28Angle Closure Glaucoma: Treatment
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
01:27Open Angle Glaucoma: Treatment
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
01:22Photoreceptors and Visual Pathways
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...