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02:20
Application of Mid-Pancreatectomy with End-to-End Anastomosis in Pancreatic Benign Tumors
Published on: February 9, 2024
Extended surgery for advanced pancreatic endocrine tumours
M Kleine1, H Schrem, F W R Vondran
1Department of General, Visceral and Transplant Surgery, Hanover, Germany. kleine.moritz@mh-hannover.de
The British Journal of Surgery
|December 3, 2011
Summary
Extended resections for advanced pancreatic endocrine tumors are feasible, showing similar survival rates to standard procedures but with increased complications. Liver resection improved survival for patients with metastases.
Area of Science:
- Surgical Oncology
- Gastroenterology
- Endocrinology
Background:
- Pancreatic endocrine tumors (PETs) are frequently diagnosed at advanced stages with liver metastasis.
- This necessitates evaluating treatment strategies for improved patient outcomes.
Purpose of the Study:
- To investigate the impact of extended surgical resections on disease-free and disease-specific survival in advanced malignant pancreatic endocrine tumors.
- To assess the feasibility and outcomes of extended resections, including liver resection and transplantation.
Main Methods:
- Retrospective analysis of patients who underwent curative resection for PETs.
- Comparison of survival rates between patients who had extended resections versus standard pancreatic resections.
- Focus on disease-specific survival and complication rates.
Main Results:
- Extended resections, including liver, portal vein, and gastric resections, were feasible in 13 of 41 patients.
- Patients undergoing extended resection showed similar disease-specific survival to those with standard resection (HR 1.50, P=0.581) but higher complication rates (OR 4.28, P=0.044).
- Liver resection was associated with improved survival in patients with liver metastases (HR 9.24, P=0.049) and similar survival to patients without metastases.
Conclusions:
- Extended surgical resection is a feasible option for locally advanced and metastatic pancreatic endocrine tumors.
- Encouraging disease-specific survival can be achieved with extended resections, particularly liver resection for metastatic disease.
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