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Updated: May 27, 2026

Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice
Published on: May 10, 2019
[A comparison of low-chirp- and notched-noise-evoked auditory brainstem response]
1Hals-Nasen-Ohrenheilunde, Universitätsklinik Bonn, Bonn, Germany. laura.muehlenberg@ukb.uni-bonn.de
Background:
In order to obtain a low-frequency specific auditory brainstem response (ABR) there are less stimuli that plege a satisfying accordance with the ABR threshold and the behavioural threshold. This study investigates the so called low-chirp-ABR as to predict a low-frequency-amblyacousia and compares it to the notched-noise-500 Hz-ABR.
Material And Methods:
We evaluated behavioural and ABR thresholds to a low-chirp respectively a 500 Hz tone presented in notched noise masking from 32 patients with a severe hearing loss at low-frequencies and 28 patients with normal hearing.
Results:
The average difference ± single standard deviation between low-chirp-ABR and behavioural threshold is 1.53 dB ± 7.68 dB in the group of patient with low-frequency hearing loss and 2.55 dB ± 5.46 dB in the group of normal hearing. On the contrary the difference between notched-noise-500 Hz- and behavioural thereshold averages 2.67 dB ± 9.29 dB (low-frequency hearing loss) respectively 8.82 dB ± 7.90 dB (normal hearing). In order to verify the equivalence between the several methods we did a equivalence test that shows that low-chip-ABR and behavioural threshold can be considered as equal to obtain a low-frequency threshold. In contrast the comparison of notched-noise-500 Hz-ABR and behavioural threshold proves no equivalence.
Conclusion:
We detected a significant equivalence between low-chirp-ABR and pure-tone audiometric. The ABR to a low-chirp stimulus seems to be rather precise in contrast to the notched-noise-500 Hz-evoked-ABR in order to diagnose a low-frequency-hearing loss.

