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GPR48 increases mineralocorticoid receptor gene expression.

Jiqiu Wang1, Xiaoying Li, Yingying Ke

  • 1Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrinology and Metabolism, Shanghai Key Laboratory for Endocrine Tumors and E-Institute of Shanghai Universities, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Journal of the American Society of Nephrology : JASN
|December 3, 2011
PubMed
Summary

G protein-coupled receptor 48 (GPR48) enhances mineralocorticoid receptor (MR) expression, improving aldosterone response and electrolyte balance. This suggests GPR48 may be a potential cause of pseudohypoaldosteronism type 1.

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