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Related Experiment Video

Updated: May 27, 2026

Nano-Differential Scanning Fluorimetry for Screening in Fragment-based Lead Discovery

Nano-Differential Scanning Fluorimetry for Screening in Fragment-based Lead Discovery

Published on: May 16, 2021

DMAN: a Java tool for analysis of multi-well differential scanning fluorimetry experiments.

Conan K Wang¹, Saroja K Weeratunga, Chris M Pacheco

¹Structural Chemistry Program, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, Queensland 4111, Australia. conan.wang@griffith.edu.au

Bioinformatics (Oxford, England)

|December 3, 2011

Summary

A new software tool, DMAN, simplifies the analysis of multi-well plate data from differential scanning fluorimetry (DSF) experiments. This user-friendly application aids structural biology research by streamlining protein-ligand interaction studies.

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Last Updated: May 27, 2026

Nano-Differential Scanning Fluorimetry for Screening in Fragment-based Lead Discovery

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Published on: May 16, 2021

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Area of Science:

Structural Biology
Biophysics

Background:

Differential scanning fluorimetry (DSF) is a rapid technique for studying protein-ligand interactions.
Analysis of multi-well plate data from DSF experiments can be complex.

Purpose of the Study:

To develop a novel, user-friendly software tool for analyzing multi-well plate data from DSF experiments.
To enhance the efficiency and accessibility of structural biology research involving protein-ligand interactions.

Main Methods:

Developed DMAN, a Java-implemented software tool for cross-platform compatibility.
DMAN allows user-defined multi-well plate layouts for data annotation and analysis.
Integrated automated statistical tests and graphical tools for comprehensive data interpretation.

Main Results:

DMAN provides a user-friendly interface for analyzing DSF multi-well plate data.
The software facilitates automated statistical analysis and data visualization.
DMAN is designed with a modular concept for future development of related applications.

Conclusions:

DMAN is an effective and accessible tool for analyzing DSF data in structural biology.
The software simplifies the study of protein-ligand interactions using multi-well plate formats.
Its modular design ensures potential for future expansion and application development.