Diastolic dysfunction in asymptomatic type 2 diabetes mellitus with normal systolic function.
Virendra C Patil1, Harsha V Patil, Kuldeep B Shah
1Department of Medicine, Krishna Institute of Medical Sciences University (KIMSU), Satara, Maharashtra, India.
Journal of Cardiovascular Disease Research
|December 3, 2011
Summary
Diabetic individuals frequently experience diastolic dysfunction, a condition linked to longer diabetes duration, higher HbA1c, obesity, and microangiopathies. Early detection and treatment are crucial for preventing heart failure in diabetic patients.
Area of Science:
- Cardiology
- Endocrinology
- Diabetology
Background:
- Heart failure incidence is notably high in diabetic individuals, even without co-existing hypertension or coronary artery disease.
- Diabetic cardiomyopathy is a significant concern, contributing to increased cardiovascular morbidity and mortality.
Purpose of the Study:
- To investigate the prevalence of left ventricular diastolic dysfunction in type 2 diabetes mellitus patients.
- To explore the relationship between diastolic dysfunction and factors such as age, diabetes duration, HbA1c, obesity, and diabetic microangiopathies.
Main Methods:
- A prospective case-control study involving 127 type 2 diabetes patients (duration > 5 years) and 100 healthy controls.
- Echocardiography was utilized to evaluate left ventricular diastolic function in all participants.
- Data on age, diabetes duration, HbA1c, obesity indices, and presence of microangiopathies were collected.
Main Results:
- Diastolic dysfunction was significantly more prevalent in diabetic subjects (54.33%) compared to controls (11%, P < 0.001).
- Longer diabetes duration (11-15 years), elevated HbA1c (>7.5%), and obesity indices (waist circumference, waist-to-hip ratio) were associated with higher rates of diastolic dysfunction (P < 0.02).
- Diastolic dysfunction was frequently observed in diabetic patients with autonomic neuropathy and retinopathy.
Conclusions:
- The study highlights a high incidence of asymptomatic diastolic dysfunction in diabetic patients.
- Findings indicate a strong correlation between diastolic dysfunction and diabetes duration, glycemic control (HbA1c), obesity, and microvascular complications.
- Early diagnosis and management of diastolic dysfunction are recommended to mitigate cardiovascular risk and prevent heart failure progression in diabetic individuals.
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