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Related Experiment Video

Updated: May 27, 2026

Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction
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Isolated ipsilateral nipple recurrence: important lessons to learn.

Abdullah Suhami Shahrun Niza1, Muhammad Rohaizak, Ibrahim Naqiyah

  • 1Department of Surgery, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaakub Latiff, Bandar Tun Razak, 56000 Kuala Lumpur, Malaysia.

The Malaysian Journal of Medical Sciences : MJMS
|December 3, 2011
PubMed
Summary
This summary is machine-generated.

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Isolated nipple tumor recurrence after breast-conserving surgery and radiotherapy is rare. This case highlights the importance of comprehensive assessment for accurate diagnosis and management of such unusual breast cancer recurrences.

Area of Science:

  • Oncology
  • Surgical Oncology
  • Radiotherapy

Background:

  • Breast cancer recurrence commonly occurs locally, often in surgical scars or other breast quadrants.
  • Nipple recurrence following breast-conserving surgery (BCS) and radiotherapy is exceptionally rare, with unclear etiology.
  • Potential causes include involved surgical margins or occult nipple-areolar complex involvement.

Observation:

  • A 44-year-old Indian woman presented with recurrent tumor on her right nipple post-BCS, chemotherapy, and radiotherapy.
  • Mammography showed no typical malignancy features.
  • Histopathology confirmed malignant growth infiltrating the dermis and underlying breast tissue.

Findings:

  • Completion mastectomy was performed, followed by Taxane-based chemotherapy.
Keywords:
breast-conserving surgerydiagnosisnipplerecurrencesurgical oncology

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  • Nipple recurrence can mimic other nipple pathologies, such as Paget's disease.
  • This case confirms the occurrence of isolated nipple recurrence after BCS and adjuvant radiotherapy.
  • Implications:

    • Accurate diagnosis requires comprehensive assessment, including mammography and biopsy.
    • Nipple recurrence necessitates a distinct management strategy.
    • Further research is needed to understand the mechanisms and optimize treatment for this rare presentation.