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Increased oxidative stress in patients with familial Mediterranean fever during attack period

L Ediz1, H Ozkol, I Tekeoglu

  • 1Yuzuncu Yil University, Medical Faculty, Physical Medicine-Rehabilitation and Rheumatology Department, Van, Turkey. leventediz@gmail.com

African Health Sciences
|December 3, 2011
PubMed
Abstract

Insights

Familial Mediterranean fever (FMF) patients exhibit increased oxidative stress during attack periods (AP), indicated by higher malondialdehyde (MDA) and protein carbonyl (PC) levels. Antioxidant enzyme activities were lower during attacks, suggesting a potential role in FMF pathogenesis.

Area of Science:

  • Biochemistry
  • Immunology
  • Genetics

Background:

  • Familial Mediterranean fever (FMF) is a genetic autoinflammatory disorder.
  • Oxidative stress plays a role in various inflammatory conditions.
  • Understanding oxidant-antioxidant balance in FMF is crucial for management.

Purpose of the Study:

  • To investigate oxidant and antioxidant status in FMF patients during attack periods (AP) and attack-free periods (AFP).
  • To assess malondialdehyde (MDA), protein carbonyl (PC), glutathione (GSH), antioxidant vitamins (A, C, E), catalase (CAT), and glutathione peroxidase (GSH-Px) levels.

Main Methods:

  • Serum and whole blood samples were collected from FMF patients during AP and AFP, and from healthy controls (HC).
  • Levels of MDA, PC, GSH, vitamins A, C, E, and activities of CAT and GSH-Px were measured.

Main Results:

  • Significantly higher MDA and PC levels were observed in FMF patients during AP compared to AFP and HC groups.
  • CAT and GSH-Px activities were significantly lower in the FMF-AP group compared to the HC group.
  • No significant differences in antioxidant vitamin levels were found between the groups.

Conclusions:

  • FMF patients experience increased oxidative stress during AP.
  • Elevated MDA and PC, with reduced antioxidant enzyme activity, may serve as biomarkers to distinguish AP from AFP.
  • Further multicenter studies are needed to validate these findings and explore antioxidant supplementation's role in FMF.
Keywords:
Antioxidant enzymesAntioxidant vitaminsFamilial Mediterranean feverLipid peroxidationProtein oxidation

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