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Related Concept Videos

Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
Lipids: Dietary Sources and Requirements01:18

Lipids: Dietary Sources and Requirements

Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ meats, shellfish,...
Lipid-derived Compounds in the Human Body01:31

Lipid-derived Compounds in the Human Body

Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various  biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin, delayed...
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...

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Related Experiment Video

Updated: May 27, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

[What about HDL cholesterol?].

Michel Farnier1

  • 1Le Point médical, 21000 Dijon. michelfarnier@nerim.net

La Revue Du Praticien
|December 6, 2011
PubMed
Summary
This summary is machine-generated.

Low levels of high-density lipoprotein cholesterol (HDL-C) increase cardiovascular risk. Lifestyle changes and therapies like nicotinic acid can raise HDL-C, but new strategies require clinical validation.

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High-Density Lipoprotein-Specific Phospholipid Efflux Assay
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High-Density Lipoprotein-Specific Phospholipid Efflux Assay

Published on: September 30, 2025

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Last Updated: May 27, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

High-Density Lipoprotein-Specific Phospholipid Efflux Assay
07:08

High-Density Lipoprotein-Specific Phospholipid Efflux Assay

Published on: September 30, 2025

Area of Science:

  • Cardiovascular Medicine
  • Metabolic Disorders
  • Lipid Metabolism

Context:

  • Low high-density lipoprotein cholesterol (HDL-C) is a known cardiovascular disease risk factor.
  • HDL-C levels alone do not fully represent HDL functionality or reverse cholesterol transport.
  • Low HDL-C often coexists with type 2 diabetes, metabolic syndrome, and abdominal obesity, forming an atherogenic dyslipidemia profile.

Purpose:

  • To review the association between low HDL-C and cardiovascular risk.
  • To discuss the complexities of HDL metabolism and its clinical implications.
  • To explore current and emerging therapeutic strategies for increasing HDL-C.

Summary:

  • Epidemiological data link low HDL-C to increased cardiovascular risk, though genetic data are conflicting.
  • Lifestyle interventions (weight loss, exercise, smoking cessation) improve HDL-C.
  • Nicotinic acid is currently the most effective drug for raising HDL-C, with ongoing interest in novel therapies.

Impact:

  • Highlights the clinical significance of low HDL-C and associated metabolic conditions.
  • Emphasizes the need for comprehensive assessment beyond just HDL-C levels.
  • Underscores the importance of validating new HDL-raising therapies through rigorous clinical trials.