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Related Experiment Video

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Corneal and Limbal Alkali Injury Induction Using a Punch-Trephine Technique in a Mouse Model

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The kallikrein/kinin system in ocular function.

¹Department of Cell and Molecular Pharmacology, Medical University of South Carolina, Charleston, South Carolina 29425, USA. webbj@musc.edu

Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics

|December 6, 2011

Summary

The ocular kallikrein/kinin system, involving plasma and tissue kallikreins, is present in the eye. Understanding its role in ocular functions and diseases may reveal new therapeutic targets.

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Area of Science:

Ocular biology
Biochemistry
Physiology

Background:

The kallikrein/kinin system involves plasma and tissue kallikreins, producing bradykinin and kallidin from kininogens.
This system plays roles in coagulation, inflammation, and cardiovascular/renal homeostasis.
Its function in the eye is an emerging area of research.

Purpose of the Study:

To review the current knowledge of the ocular kallikrein/kinin system.
To contextualize its ocular functions with roles in other organs.
To explore its potential as a therapeutic target for ocular dysfunction.

Main Methods:

Literature review of existing research on the ocular kallikrein/kinin system.
Analysis of the presence and localization of system components within ocular tissues.
Synthesis of proposed roles in ocular physiology and pathology.

Main Results:

All components of the kallikrein/kinin system are found within the eye.
Plasma kallikrein generates bradykinin, potentially regulating ocular blood flow and implicated in retinal edema.
Tissue kallikrein is expressed in the retina, ciliary muscle, and trabecular meshwork, possibly aiding ischemic preconditioning and aqueous humor dynamics.

Conclusions:

The ocular kallikrein/kinin system participates in key eye functions.
Dysregulation may contribute to ocular diseases like diabetic retinopathy.
Further understanding offers potential for novel therapeutic strategies for eye conditions.