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The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well

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Herbal remedies affecting coagulation: a review.

Werner Cordier¹, Vanessa Steenkamp

¹Department of Pharmacology, School of Medicine, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.

Pharmaceutical Biology

|December 6, 2011

Summary

Many herbal remedies affect blood clotting, but their safety and interactions are not fully understood. Discontinue herbal use before surgery due to unproven effects on coagulation and potential bleeding risks.

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Area of Science:

Pharmacology
Herbal Medicine
Hematology

Background:

Herbal remedies are widely used for various conditions, including blood disorders.
Some herbal preparations can alter clotting time by disrupting the coagulation cascade.

Purpose of the Study:

To compile a list of plants investigated for their effects on the coagulation cascade.
To review the scientific literature on herbal remedies and their impact on blood coagulation.

Main Methods:

Systematic literature search using Google Scholar, Scopus, and PubMed.
Identification and compilation of studies on herbal remedies affecting coagulation.

Main Results:

Sixty-five herbal remedies with antiplatelet, anticoagulant, or coagulating properties were identified.
Key bioactive compounds include polyphenols, taxanes, coumarins, saponins, fucoidans, and polysaccharides.

Conclusions:

Most research on herbal effects on coagulation relies on in vitro data.
Evidence on bleeding risks is contradictory, and herb-drug interactions are a concern.
Discontinue herbal preparations before surgery due to unproven safety and undetermined effects on blood parameters.