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Optimization of Crystal Growth for Neutron Macromolecular Crystallography

Optimization of Crystal Growth for Neutron Macromolecular Crystallography

Published on: March 13, 2021

Gel-induced selective crystallization of polymorphs.

Ying Diao¹, Kristen E Whaley, Matthew E Helgeson

¹Novartis-MIT Center for Continuous Manufacturing and Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, E19-502b, Cambridge, Massachusetts 02139, USA.

Journal of the American Chemical Society

|December 6, 2011

Summary

This summary is machine-generated.

Polymer microgels control crystal polymorphism by influencing nucleation kinetics and confinement. This research advances understanding of crystallization in confined environments and at complex interfaces.

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Methods of Ex Situ and In Situ Investigations of Structural Transformations: The Case of Crystallization of Metallic Glasses

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Published on: June 7, 2018

Area of Science:

Materials Science
Chemical Engineering
Physical Chemistry

Background:

Polymorphism in confined environments is poorly understood, especially kinetics.
The role of substrate local structure in polymorphism is often neglected.
Nanoporous materials offer potential for controlling polymorph crystallization.

Purpose of the Study:

Investigate polymer microgels for controlling polymorph crystallization from solution.
Systematically study effects of nanoconfinement and interfacial interactions on polymorphic outcomes.
Advance fundamental understanding of crystallization at complex interfaces.

Main Methods:

Utilized polymer microgels with tunable microstructure.
Investigated gel-induced nucleation kinetics.
Analyzed polymorphic outcomes based on polymer microstructure and chemical composition.

Main Results:

Polymer microgels significantly improved polymorph selectivity.
Polymorphic outcomes strongly correlated with nucleation kinetics.
Results sensitive to polymer microstructure and chemical composition.

Conclusions:

Polymer microgels are promising for controlling crystal polymorphism.
Nucleation-templating and spatial confinement are key to selectivity.
Study advances understanding of crystallization in confined environments.