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Coagulation factor VII R353Q polymorphism and the risk of puerperal cerebral venous thrombosis

T P Kruthika-Vinod1, Dindagur Nagaraja, Rita Christopher

  • 1Department of Neurochemistry, National Institute of Mental Health and Neuro sciences, Post Box 2900, Hosur Road, Bangalore 560029, India.

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
|December 6, 2011
PubMed

Puerperal cerebral venous thrombosis (CVT) is a relatively common form of stroke in young women in India. The blood coagulation factor VII (FVII) R353Q polymorphism increases the risk for venous thrombosis. Our aim was to investigate the association of FVII R353Q polymorphism with the risk of puerperal CVT. A total of 100 women with puerperal CVT and 102 age-matched women without postpartum complications were investigated. FVII R353Q genotypes were identified using restriction fragment length polymorphism analysis. Our results showed that the homozygous FVII 353QQ genotype was present in 9% and 8% of patients and controls, respectively; and 42% of patients and 31.4% of controls had the heterozygous 353RQ genotype (odds ratio = 1.55, 95% confidence interval = 0.89-2.70; p = 0.243). Our findings suggest that the FVII R353Q polymorphism is not associated with increased risk for CVT occurring during the puerperal period in Indian women.

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