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Updated: May 27, 2026

Reprogramming Pancreatic Ductal Adenocarcinoma to Pluripotency
Published on: February 2, 2024
Historical origins of transdifferentiation and reprogramming
1ICREA Professor, Center for Genomic Regulation and Pompeu Fabra University, 08003 Barcelona, Spain. thomas.graf@crg.es
Abstract:
Transcription factor-induced reprogramming of specialized cells into other cell types and to pluripotency has revolutionized our thinking about cell plasticity, differentiation, and stem cells. The recent advances in this area were enabled by the confluence of a number of experimental breakthroughs that took place over the past 60 years. In this article, I give a historical and personal perspective of the events that set the stage for our current understanding of cellular reprogramming.
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