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Anorexia Nervosa

Anorexia Nervosa

Anorexia nervosa is a complex and severe eating disorder characterized by an intense fear of weight gain, an unrelenting pursuit of thinness, and a distorted body image. It often leads to dangerously low body weight relative to an individual's age and height. This disorder is marked by significant physical and psychological consequences, making it one of the most life-threatening psychiatric illnesses.
Symptoms and Physical Effects
Individuals with anorexia nervosa commonly exhibit extreme...

Bone Disorders

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

Bulimia Nervosa

Bulimia Nervosa

Bulimia nervosa is a complex and severe eating disorder characterized by a cyclical pattern of binge-and-purge eating pattern. It generally involves an episode of binge eating, followed by compensatory behaviors such as vomiting, excessive exercise, laxative use, or fasting, to prevent weight gain. Despite often maintaining a normal weight, individuals with bulimia are intensely preoccupied with their body image and harbor an overwhelming fear of gaining weight. This can contribute to the...

Role of Vitamins in Maintaining Bone Health

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...

Essential Minerals for Bone Health

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
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Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...

Hormones and Bone Tissue

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
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Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...

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Related Experiment Video

Updated: May 27, 2026

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

[Adolescent with anorexia nervosa: consequences on bone mineralization].

D Nicaise¹, M Beaumesnil, E Chaillou

¹Service de pédiatrie, centre Robert-Debré, CHU d'Angers, 4, rue Larrey, 49933 Angers cedex 09, France.

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie

|December 6, 2011

Summary

Adolescents with anorexia nervosa frequently experience bone loss, including osteopenia and osteoporosis. Early age at disease onset is linked to lower bone mineral density, but no other clinical predictors were identified.

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Assessing Activity-based Anorexia in Mice

Assessing Activity-based Anorexia in Mice

Published on: May 14, 2018

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Last Updated: May 27, 2026

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

Assessing Activity-based Anorexia in Mice

Assessing Activity-based Anorexia in Mice

Published on: May 14, 2018

Area of Science:

Pediatric Endocrinology
Adolescent Medicine
Bone Metabolism

Context:

Anorexia nervosa (AN) is associated with significant bone density abnormalities in adults.
These skeletal complications are less understood in adolescent populations with AN.
Early identification of bone loss is crucial for long-term skeletal health.

Purpose:

To determine the frequency and severity of bone mineralization abnormalities in adolescent females with AN.
To identify potential predictive factors for these skeletal complications.

Summary:

A retrospective study analyzed 39 female adolescents with AN, assessing bone mineral density (BMD) using dual-energy X-ray absorptiometry.
Over half (51%) had osteopenia, and 5% had osteoporosis. BMD Z-scores did not correlate with assessed clinical or biological parameters.
However, absolute BMD values correlated with age at onset, BMI, lowest weight, and BMI at densitometry, with age at onset being the only significant predictor in multivariate analysis.

Impact:

Bone loss is a significant complication of AN that can manifest during adolescence.
Systematic screening for bone density deficits is recommended in all adolescents with severe malnutrition.
No specific clinical predictor for osteoporosis or osteopenia was identified, highlighting the need for universal screening.