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Updated: May 27, 2026

Vascular Occlusion Training for Inclusion Body Myositis: A Novel Therapeutic Approach
09:01

Vascular Occlusion Training for Inclusion Body Myositis: A Novel Therapeutic Approach

Published on: June 5, 2010

[Isoniazid-induced myopathy].

N Chaouch1, M Mejid, M Zarrouk

  • 1Service de pneumologie, Pavillon, hôpital Abderrahmen Mami, Ariana, Tunisie. besnawel@yahoo.fr

Revue De Pneumologie Clinique
|December 6, 2011
PubMed
Summary
This summary is machine-generated.

Isoniazid, a tuberculosis drug, can cause rare isolated muscle damage (myopathy) without nerve involvement. Symptoms resolved upon stopping the drug, confirming drug-induced myopathy.

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Last Updated: May 27, 2026

Vascular Occlusion Training for Inclusion Body Myositis: A Novel Therapeutic Approach
09:01

Vascular Occlusion Training for Inclusion Body Myositis: A Novel Therapeutic Approach

Published on: June 5, 2010

Area of Science:

  • Neurology
  • Pharmacology
  • Musculoskeletal Diseases

Background:

  • Drug-induced myopathies are a recognized class of adverse drug reactions.
  • Isoniazid is commonly used for tuberculosis treatment.
  • Muscle disorders from isoniazid typically present as neuropathy or lupus-like syndromes.

Observation:

  • A 28-year-old male developed isolated myopathy with muscle pain, fasciculations, and weakness after five days of isoniazid treatment for tuberculosis.
  • Neurological examination and creatine phosphokinase (CPK) levels were normal.
  • Electromyography confirmed myopathy without neuropathic findings.

Findings:

  • The patient's symptoms rapidly resolved after discontinuing isoniazid.
  • Readministration of a lower dose of isoniazid caused only transient fasciculations.
  • These findings strongly suggest isoniazid-induced myopathy, even at non-toxic doses.

Implications:

  • This case highlights the potential for isoniazid to cause rare, isolated myopathy.
  • Clinicians should consider drug-induced myopathy in patients presenting with unexplained muscle symptoms during isoniazid therapy.
  • Early recognition and drug withdrawal are crucial for managing isoniazid-induced myopathy.