Activation of the immune system in the testis

The present concept for the mechanism of prolonged transplant survival in the testis suggests that lymphocyte activation is inhibited locally in this site by testicular products. As the testis produces several immunoregulatory factors, the behaviour of lymphocytes in the testis may depend on the net effect of all these factors on intralymphocytic events. In the present article, the extra- and intracellular events associated with lymphocyte activation are reviewed and the steps of lymphocyte activation which might be subject to interference by testicular factors are identified.