Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
Antihypertensive Drugs: Action of Calcium Channel Blockers01:18

Antihypertensive Drugs: Action of Calcium Channel Blockers

Calcium ions are essential to contract smooth muscle cells in blood vessels. They enter these cells through voltage-dependent calcium channels, specifically L-type calcium channels in the cell membrane. These L-type calcium channels are integral to the excitation-contraction coupling process in smooth muscle. When a stimulus is received by smooth muscle cells, their membrane depolarizes. This alteration in membrane potential instigates the opening of L-type calcium channels. As a result,...
Diabetic Neuropathy01:22

Diabetic Neuropathy

DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of dietary juglone on the oriental fruit moth Grapholita molesta (Lepidoptera: Tortricidae): growth performance and protective enzyme activity.

Journal of economic entomology·2026
Same author

M6A-modified circArhgap26 attenuates cardiac ischemia‒reperfusion injury by suppressing plakophilin-1 palmitoylation.

Signal transduction and targeted therapy·2026
Same author

Sex pheromone of Carposina coreana (Lepidoptera: Carposinidae), a key pest of traditional Chinese medicinal plant Cornus officinalis: identification, field evaluation, and trap optimization.

Pest management science·2026
Same author

Antennal morphological differences between Alate and Apterous morphs of Semiaphis heraclei (Hemiptera: Aphididae).

Journal of insect science (Online)·2026
Same author

Zinc finger BED-type containing 6 (ZBED6) ameliorates cardiac fibrosis by inhibiting Piezo1 transcription and YAP nuclear translocation.

Acta pharmacologica Sinica·2026
Same author

Retraction Note: Role of dopamine D<sub>2</sub> receptors in ischemia/reperfusion induced apoptosis of cultured neonatal rat cardiomyocytes.

Journal of biomedical science·2025

Related Experiment Video

Updated: May 27, 2026

Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes
11:00

Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes

Published on: September 18, 2017

Decrease in calcium-sensing receptor in the progress of diabetic cardiomyopathy.

Shu-zhi Bai1, Jian Sun, Hao Wu

  • 1Department of Pathophysiology, Harbin Medical University, Harbin 150086, China.

Diabetes Research and Clinical Practice
|December 6, 2011
PubMed
Summary
This summary is machine-generated.

Diabetic cardiomyopathy (DCM) involves reduced myocardial calcium-sensing receptor (CaSR) expression, impairing calcium handling. Spermine, a CaSR agonist, may prevent DCM progression by restoring calcium homeostasis.

More Related Videos

Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model
05:58

Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model

Published on: April 18, 2025

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model
06:22

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

Published on: November 29, 2024

Related Experiment Videos

Last Updated: May 27, 2026

Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes
11:00

Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes

Published on: September 18, 2017

Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model
05:58

Mouse Electroacupuncture Fixation Device Fabrication for Electroacupuncture Pretreatment in Diabetic Cardiomyopathy Mouse Model

Published on: April 18, 2025

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model
06:22

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

Published on: November 29, 2024

Area of Science:

  • Cardiology
  • Endocrinology
  • Molecular Biology

Background:

  • Diabetic cardiomyopathy (DCM) is a cardiac complication of diabetes mellitus (DM).
  • The role of the calcium-sensing receptor (CaSR) in DCM pathogenesis is not fully understood.
  • Intracellular calcium ([Ca(2+)](i)) dysregulation is a hallmark of cardiac dysfunction.

Purpose of the Study:

  • To investigate the dynamic expression of CaSR in the myocardium of diabetic rats.
  • To explore the role of CaSR in the development and progression of DCM.
  • To examine the effect of spermine, a CaSR agonist, on cardiac function in diabetic rats.

Main Methods:

  • Type 2 DM model induced by streptozotocin (STZ) in Wistar rats.
  • Echocardiography for cardiac function assessment.
  • Western blot for protein expression analysis (CaSR, PKC-α, PLN, SERCA, RyR).
  • Measurement of intracellular calcium concentration ([Ca(2+)](i)).

Main Results:

  • Diabetic rats showed decreased myocardial CaSR, RyR, and SERCA/PLN expression over time.
  • Increased intracellular calcium ([Ca(2+)](i)), PKC-α, and PLN levels were observed in diabetic rats.
  • Cardiac structure and function (systolic and diastolic) were impaired in diabetic rats.
  • Spermine treatment attenuated cardiac dysfunction and structural abnormalities.

Conclusions:

  • Myocardial CaSR expression is reduced during DCM progression.
  • Impaired intracellular calcium homeostasis is a key mechanism in DCM.
  • CaSR modulation may represent a therapeutic target for diabetic cardiomyopathy.