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Analysis of Group IV Viral SSHHPS Using In Vitro and In Silico Methods

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Published on: December 21, 2019

Acute phase proteins in animals.

¹Division of Comparative Pathology, Department of Pathology, University of Miami Miller School of Medicine, Miami, Florida, USA.

Progress in Molecular Biology and Translational Science

|December 6, 2011

Summary

This summary is machine-generated.

Acute phase proteins (APPs) are vital innate immunity biomarkers that indicate inflammation, infection, and stress across all animal species. These proteins aid in disease diagnosis, prognosis, and monitoring in veterinary medicine and research.

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Area of Science:

Veterinary immunology
Biomarker discovery
Animal health

Background:

Acute phase proteins (APPs) were identified in the early 1900s as indicators of infectious disease.
APPs are integral to the acute phase response (APR), a key component of innate immunity.
APP levels increase in response to inflammation, infection, neoplasia, stress, and trauma, making them valuable biomarkers.

Purpose of the Study:

To review the significance of acute phase proteins (APPs) in animal health.
To highlight the diagnostic, prognostic, and monitoring applications of APPs in veterinary medicine.
To emphasize the broad applicability of APPs across species and research fields.

Main Methods:

Literature review of studies on acute phase proteins in animals.
Analysis of the role of APPs in innate immunity and disease states.
Discussion of the utility of APPs as biomarkers in various animal populations.

Main Results:

Acute phase proteins are present in all animal species, with variations in major APP types.
APP elevations are associated with diverse conditions including inflammation, infection, and trauma.
Studies confirm APP relevance for diagnosis, detection, and monitoring of subclinical disease in animals.

Conclusions:

Acute phase proteins are conserved biomarkers across the animal kingdom, crucial for innate immunity.
Standardized assays make APPs readily available for clinical and research applications in veterinary medicine.
APP analysis offers valuable insights for disease management and research in all animal species.