Animal models of molecular pathology systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is an autoimmune disease that affects multiple organ systems. A hallmark of SLE is the production of antinuclear antibodies against nuclear antigens such as chromatin and DNA. High levels of autoAbs promote the formation of immune complexes which can lead to the development of glomerulonephritis and progress to end-stage renal failure. Although the exact etiology of SLE is unknown, it is thought to be multifactorial in nature. A combination of environmental, hormonal, and a predisposed genetic background lead to the development of this disorder. Here, we review the various mouse models that have been used to study SLE and discuss how their study has led to a better understanding of the genetic and cellular factors involved in the development of systemic autoimmunity and lupus-like clinical symptoms. We also review the mouse studies that have explored the molecular pathways that are altered in this disease and the investigation of their therapeutic potentials.