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Priming microenvironments dictate cytokine requirements for T helper 17 cell lineage commitment

Wei Hu1, Ty Dale Troutman, Ramakrishna Edukulla

  • 1Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Immunity
|December 6, 2011
PubMed
Summary

Cytokine requirements for T helper 17 (Th17) cell differentiation vary by tissue site. Interleukin-6 (IL-6) is crucial for skin and mucosal priming, but not splenic priming, while Interleukin-1 (IL-1) is essential in all tissues.

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