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Related Experiment Video

Updated: May 27, 2026

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

Temporary targeted hemostasis to facilitate bloodless partial nephrectomy.

Niall J Harty¹, Alireza Moinzadeh, Sebastian Flacke

¹Department of Urology, Lahey Clinic, Burlington, Massachusetts 01805, USA.

|December 6, 2011

Summary

Lumagel effectively creates a bloodless field for partial nephrectomy in pigs and calves, allowing safe and efficient kidney surgery without global ischemia. This technique ensures reliable blood flow interruption and restoration.

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Application of Hemostatic Devices in Laparoscopic Hepatectomy

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Application of Hemostatic Devices in Laparoscopic Hepatectomy

Application of Hemostatic Devices in Laparoscopic Hepatectomy

Published on: April 19, 2022

Area of Science:

Urology
Surgical Innovation
Medical Device Technology

Background:

Previous robotic-assisted techniques for partial nephrectomy were extended to larger animal models.
The study aimed to replicate human-like vessel diameters in pigs and calves.
Achieving a bloodless operative field is crucial for complex partial nephrectomies.

Purpose of the Study:

To evaluate Lumagel's efficacy in achieving temporary, targeted renal artery occlusion during partial nephrectomy.
To compare Lumagel with traditional arterial clamping for flow interruption.
To assess the safety and feasibility of Lumagel in a porcine and calf model for open and laparoscopic partial nephrectomy.

Main Methods:

Ten animals (7 pigs, 3 calves) underwent renal artery flow interruption using either Lumagel or arterial clamping.
Lumagel was administered intra-arterially under fluoroscopic guidance.
Animals, except for the first pig and calf, underwent partial nephrectomy after flow interruption.

Main Results:

Lumagel successfully achieved targeted blood flow interruption while preserving circulation to uninvolved renal tissue.
Hemostasis was maintained for at least 30 minutes, with negligible blood loss in most cases.
Surgical resection times averaged 11 minutes (open) and 23.3 minutes (laparoscopic); Lumagel flow return averaged 7 minutes versus 2.5 minutes for clamping.

Conclusions:

Lumagel offers a reliable method for intraluminal blood flow interruption and restoration in renal arteries.
This technique facilitates blood-free partial nephrectomy, potentially avoiding global renal ischemia.
Lumagel shows promise for improving surgical outcomes in partial nephrectomy procedures.