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Related Concept Videos

Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
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The Skin Microbiota

The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...
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Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Defense Against Bacterial Pathogens

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Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
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Clinical Significance of Antibiotic Resistance

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Improved Enzyme Protection Assay to Study Staphylococcus aureus Internalization and Intracellular Efficacy of Antimicrobial Compounds
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Improved Enzyme Protection Assay to Study Staphylococcus aureus Internalization and Intracellular Efficacy of Antimicrobial Compounds

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Host-pathogen interactions between the skin and Staphylococcus aureus.

Sheila Krishna1, Lloyd S Miller

  • 1Department of Medicine, Division of Dermatology, University of California Los Angeles, Los Angeles, CA 90095, United States.

Current Opinion in Microbiology
|December 6, 2011
PubMed
Summary
This summary is machine-generated.

Staphylococcus aureus causes most human skin infections. This review explores how this bacterium, Staphylococcus aureus, interacts with skin defenses to cause infection and colonization.

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Last Updated: May 27, 2026

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Development and Assessment of Intracellular Infection Models for Staphylococcus aureus

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Area of Science:

  • Microbiology
  • Immunology
  • Dermatology

Background:

  • Staphylococcus aureus is a primary cause of human bacterial skin infections.
  • Skin possesses unique defense mechanisms, including a protective corneal layer, epidermis, and dermis.
  • S. aureus employs various strategies to overcome these cutaneous defenses for colonization and infection.

Purpose of the Study:

  • To review host-pathogen interactions at the skin interface during Staphylococcus aureus colonization and infection.
  • To elucidate the balance between host immunity and bacterial virulence factors in skin infections.

Main Methods:

  • This is a review article, synthesizing existing research.
  • Focuses on host-pathogen interactions at the skin interface.
  • Examines mechanisms of Staphylococcus aureus colonization and pathogenesis.

Main Results:

  • Staphylococcus aureus effectively evades skin's immune defenses.
  • The corneal layer and other skin structures present a barrier S. aureus must overcome.
  • A complex interplay exists between S. aureus virulence factors and host immune responses.

Conclusions:

  • Understanding host-pathogen dynamics is crucial for combating S. aureus skin infections.
  • Further research into S. aureus evasion strategies can inform therapeutic approaches.
  • The skin's unique architecture plays a significant role in susceptibility and defense against S. aureus.