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Updated: May 27, 2026

Operant Protocols for Assessing the Cost-benefit Analysis During Reinforced Decision Making by Rodents
07:05

Operant Protocols for Assessing the Cost-benefit Analysis During Reinforced Decision Making by Rodents

Published on: September 10, 2018

Economic consequences and potential benefits.

Bruno Fautrel1, Suzanne M M Verstappen, Annelies Boonen

  • 1Paris 6 - Pierre et Marie Curie University, APHP Pitie-Salpetriere Hospital, Department of Rheumatology, France. bruno.fautrel@psl.aphp.fr

Best Practice & Research. Clinical Rheumatology
|December 6, 2011
PubMed
Summary
This summary is machine-generated.

Rheumatoid arthritis (RA) significantly increases healthcare costs and reduces work productivity, primarily due to physical function decline. Optimizing biologic treatments requires better patient selection and identifying those who can stop therapy to improve cost-effectiveness.

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Last Updated: May 27, 2026

Operant Protocols for Assessing the Cost-benefit Analysis During Reinforced Decision Making by Rodents
07:05

Operant Protocols for Assessing the Cost-benefit Analysis During Reinforced Decision Making by Rodents

Published on: September 10, 2018

Area of Science:

  • Rheumatology
  • Health Economics
  • Pharmacoeconomics

Background:

  • Established rheumatoid arthritis (RA) leads to substantial healthcare resource utilization and lost work productivity.
  • Physical function impairment, worsening with disease duration, is a key driver of these economic burdens.
  • Significant cost variations exist across regions due to differences in care access, provision, and pricing of healthcare and lost work.

Purpose of the Study:

  • To analyze the economic impact of rheumatoid arthritis (RA).
  • To evaluate the cost-utility of biologic therapies in established RA.
  • To identify strategies for optimizing biologic use in RA treatment sequences.

Main Methods:

  • Literature review on cost of illness in RA.
  • Analysis of cost-utility ratios for biologic agents versus non-biologic disease-modifying anti-rheumatic drugs (DMARDs).
  • Exploration of factors influencing cost variations and treatment optimization.

Main Results:

  • Biologic therapies in established RA show high cost-utility ratios compared to optimizing non-biologic DMARD sequences.
  • Physical function impairment is the primary determinant of RA-associated costs.
  • Significant variations in costs are observed, influenced by healthcare access, provision, and pricing.

Conclusions:

  • Optimizing biologic use in RA necessitates improved patient selection for those unresponsive to non-biologic DMARDs.
  • Identifying patient groups who can discontinue biologics is crucial for cost-effectiveness.
  • Reducing biologic prices is essential for improving their cost-utility in RA management.