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Updated: Dec 23, 2025

SUMO-Binding Entities SUBEs as Tools for the Enrichment, Isolation, Identification, and Characterization of the SUMO Proteome in Liver Cancer
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SUMO-Binding Entities SUBEs as Tools for the Enrichment, Isolation, Identification, and Characterization of the SUMO Proteome in Liver Cancer

Published on: November 1, 2019

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SUMOylation in carcinogenesis

Kira Bettermann1, Martin Benesch, Serge Weis

  • 1Institute of Pathology, Medical University of Graz, Austria.

Cancer Letters
|December 6, 2011
PubMed

Insights

SUMOylation, a key protein modification, is increasingly linked to cancer development. This review explores SUMOylation

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • SUMOylation is a reversible post-translational modification involving small ubiquitin-like modifiers (SUMO).
  • SUMO proteins regulate nuclear organization and cell viability.
  • SUMOylation is upregulated in processes like cell growth, differentiation, senescence, oxidative stress, and apoptosis, all linked to cancer.

Purpose of the Study:

  • To review the implications of SUMOylation in carcinogenesis.
  • To highlight SUMOylation's role as a cell cycle regulator in cancer.
  • To discuss novel therapeutic strategies targeting SUMOylation.

Main Methods:

  • Literature review of studies on SUMOylation and cancer.
  • Analysis of SUMOylation's impact on cell cycle regulation.
  • Exploration of therapeutic targets within the SUMO pathway.

Main Results:

  • SUMOylation plays a significant role in various stages of carcinogenesis.
  • SUMOylation impacts cell cycle regulation, influencing cancer progression.
  • Differential SUMOylation patterns across cancer subtypes present complex challenges.

Conclusions:

  • SUMOylation is a critical factor in cancer development and progression.
  • Targeting SUMOylation offers potential for novel cancer therapies.
  • Further research is needed to fully elucidate SUMOylation's complex role in diverse cancers.

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