Related Experiment Video
Updated: May 27, 2026

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair
Published on: October 16, 2021
Mean pulmonary arterial pressure after percutaneous mitral valvuloplasty predicts long-term adverse outcomes
Elisabete Jorge1, Rui Baptista, Henrique Faria
1Cardiology Department, Coimbra Hospital and Medical School, Coimbra, Portugal. elisabetejorge@gmail.com
Introduction And Aim:
Percutaneous mitral valvuloplasty (PMV) is an effective treatment option for mitral stenosis (MS), but its success is assessed on the basis of clinical and echocardiographic outcomes in studies with relatively short follow-up. We aimed to characterize a cohort of patients undergoing PMV with long-term follow-up and to determine independent predictors of post-PMV mitral re-intervention and event-free survival.
Methods:
We studied 91 consecutive patients with MS who underwent PMV with a median clinical follow-up duration of 99 months. Two endpoints were considered: post-PMV mitral re-intervention (PMV or mitral surgery) and a composite clinical events endpoint including cardiovascular death, mitral valve re-intervention and hospital admission due to decompensated heart failure. We compared patients who required post-PMV mitral re-intervention with those who did not during follow-up.
Results:
The study population included 83.5% females and mean age was 48.9±13.9 years. The 1-, 3-, 5-, 7- and 9-year rates of clinical event-free survival were 93.0±2.8%, 86.0±3.9%, 81.0±4.4%, 70.6±5.6%, and 68.4±5.8%, respectively. The 1-, 3-, 5-, 7- and 9-year rates of mitral re-intervention-free survival were 98.8±1.2%, 97.5±1.7%, 92.1±3.1%, 85.5±4.5%, and 85.5±4.5%, respectively. The median time to mitral re-intervention was 6.2 years. Patients who required mitral re-intervention during follow-up were younger (43.3 vs. 51.2 years, p=0.04) and had higher pre- and post-PMV mitral gradient (14.9 vs. 11.5 mmHg, p=0.02 and 6.4 vs. 2.1 mmHg, p<0.001) and higher post-PMV mean pulmonary artery pressure (mPAP) (30.0 vs. 23.2 mmHg, p=0.01). In a Cox proportional hazards model, mPAP ≥25 mmHg was the sole predictor of both mitral re-intervention (HR 5.639 [1.246-25.528], p=0.025) and clinical events (HR 3.622 [1.070-12.260], p=0.039).
Conclusion:
In our population, immediate post-PMV mPAP was the sole predictor of post-PMV mitral intervention. These findings may help identify patients in need of closer post-PMV follow-up.
Insights
Immediate post-percutaneous mitral valvuloplasty (PMV) mean pulmonary artery pressure (mPAP) predicts mitral re-intervention in mitral stenosis (MS) patients. Higher mPAP identifies individuals requiring closer follow-up after PMV.
Area of Science:
- Cardiology
- Interventional Cardiology
- Cardiac Surgery
Background:
- Percutaneous mitral valvuloplasty (PMV) is a key treatment for mitral stenosis (MS).
- Long-term outcomes and predictors of re-intervention after PMV require further characterization.
- Existing studies often have limited follow-up durations.
Purpose of the Study:
- To assess long-term outcomes in patients undergoing PMV for MS.
- To identify independent predictors of mitral re-intervention and event-free survival post-PMV.
- To inform patient selection and follow-up strategies.
Main Methods:
- A cohort of 91 consecutive MS patients undergoing PMV was studied.
- Median clinical follow-up was 99 months.
- Endpoints included mitral re-intervention and a composite clinical events outcome.
Main Results:
- Long-term event-free survival rates were observed over 9 years.
- Mitral re-intervention-free survival rates were also tracked.
- Higher post-PMV mean pulmonary artery pressure (mPAP) ≥25 mmHg was the sole predictor of mitral re-intervention and clinical events.
Conclusions:
- Immediate post-PMV mPAP is a critical predictor of subsequent mitral re-intervention.
- Elevated mPAP identifies patients at higher risk for adverse outcomes.
- These findings support closer post-PMV monitoring for high-risk individuals.
Related Concept Videos
Mitral Valve Prolapse II: Assessment and Management
Mitral Valve Prolapse III: Nursing Management
Mitral Stenosis II: Clinical features and Diagnostic Tests
Mitral Valve Prolapse I: Introduction
Mitral Stenosis I: Introduction
Mitral Stenosis III: Medical Management
