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Label-free virus detection using silicon photonic microring resonators
Melinda S McClellan1, Leslie L Domier, Ryan C Bailey
1Department of Chemistry, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, IL 61801, USA.
Biosensors & Bioelectronics
|December 6, 2011
Summary
This study introduces silicon photonic microring resonators for rapid, label-free virus detection. This innovative method offers a cost-effective solution for identifying plant viruses like Bean pod mottle virus in under 45 minutes.
Area of Science:
- Nanotechnology
- Biotechnology
- Materials Science
Background:
- Viruses pose significant threats to human health and agriculture.
- Current virus detection methods often require extensive sample preparation and time.
- Limitations exist in serological methods due to delayed immune response detection.
Purpose of the Study:
- To develop a fast, cost-effective virus detection method with reduced sample preparation.
- To apply silicon photonic microring resonators for direct, label-free virus detection.
- To demonstrate the quantitative detection of intact viruses in complex matrices.
Main Methods:
- Utilized silicon photonic microring resonators for label-free virus detection.
- Employed a model system for quantitative detection of Bean pod mottle virus.
- Simplified sample preparation involving grinding leaf samples in buffer.
Main Results:
- Achieved a limit of detection of 10 ng/mL for Bean pod mottle virus.
- Successfully identified infected leaves from healthy controls.
- Demonstrated a total analysis time of less than 45 minutes.
Conclusions:
- Silicon photonic microring resonators offer a promising analytical tool for virus detection.
- The technology is scalable and capable of multiplexing for broader applications.
- This method provides a rapid and efficient alternative to traditional virus detection techniques.
