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Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists01:27

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists

5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists01:28

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates these...

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Related Experiment Video

Updated: May 27, 2026

Electrochemotherapy of Tumours
03:57

Electrochemotherapy of Tumours

Published on: December 15, 2008

IgE and chemotherapy.

Martin H Bluth1

  • 1Department of Pathology, Wayne State University School of Medicine, Detroit, MI 48201, USA. mbluth@med.wayne.edu

Cancer Immunology, Immunotherapy : CII
|December 6, 2011
PubMed
Summary

Chemotherapy

Area of Science:

  • Oncology
  • Immunology
  • Pharmacology

Background:

  • The interplay between chemotherapy and immunoglobulin E (IgE)-mediated immune responses is not fully elucidated.
  • Understanding this relationship is crucial for managing cancer patients, as chemotherapy can influence immune reactions.

Purpose of the Study:

  • To review the effects of chemotherapy on immunoglobulins, particularly IgE.
  • To explore related biological processes like hypersensitivity reactions.
  • To propose management strategies for cancer patients concerning these interactions.

Main Methods:

  • Literature review of studies examining chemotherapy's impact on immunoglobulin E.
  • Analysis of biological processes including hypersensitivity.
  • Development of theoretical models for clinical application.

More Related Videos

Acupoint Application Combined with Acupressure as an Adjunctive Therapy for Chemotherapy-Induced Nausea and Vomiting
05:56

Acupoint Application Combined with Acupressure as an Adjunctive Therapy for Chemotherapy-Induced Nausea and Vomiting

Published on: June 21, 2024

Related Experiment Videos

Last Updated: May 27, 2026

Electrochemotherapy of Tumours
03:57

Electrochemotherapy of Tumours

Published on: December 15, 2008

Acupoint Application Combined with Acupressure as an Adjunctive Therapy for Chemotherapy-Induced Nausea and Vomiting
05:56

Acupoint Application Combined with Acupressure as an Adjunctive Therapy for Chemotherapy-Induced Nausea and Vomiting

Published on: June 21, 2024

Main Results:

  • Chemotherapy can modulate IgE levels and related immune phenomena.
  • These modulations may influence hypersensitivity reactions in cancer patients.
  • The precise causal or resultant effects require further investigation.

Conclusions:

  • Chemotherapy significantly impacts IgE-related immunomodulation.
  • Effective management strategies are needed to address chemotherapy-induced immune changes in cancer patients.
  • Further research is warranted to refine understanding and clinical protocols.