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Related Concept Videos

Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:

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Related Experiment Video

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Asthma Detection Research Based on Voice Signal Processing and Machine Learning
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Asthma Detection Research Based on Voice Signal Processing and Machine Learning

Published on: July 22, 2025

Cough variant asthma: lessons learned from deep inspirations.

M Diane Lougheed1, Scott E Turcotte, Thomas Fisher

  • 1Department of Medicine, Queen's University, 102 Stuart Street, Kingston, ON K7L 2V6, Canada. mdl@queensu.ca

Lung
|December 6, 2011
PubMed
Summary

The exact causes of cough variant asthma remain unclear. Altered small airway function and changes in the protective effect of deep breaths may distinguish it from typical asthma.

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Area of Science:

  • Pulmonology
  • Respiratory Medicine
  • Clinical Immunology

Background:

  • The pathophysiology of cough variant asthma (CVA) is not well understood.
  • Mechanisms differentiating CVA (cough predominant) from typical asthma (wheeze predominant) are undetermined.
  • Previous hypotheses include varying wheeze thresholds, cough sensitivity, and small airway function.

Purpose of the Study:

  • To investigate the underlying pathophysiological mechanisms differentiating cough variant asthma from typical asthma.
  • To explore the role of small airway function in the distinct symptomatology of CVA.
  • To determine if altered bronchoprotective effects of deep inspiration are a key factor.

Main Methods:

  • Utilized high-dose methacholine challenge testing.
  • Assessed small airway function.
  • Evaluated the bronchoprotective effect of deep inspiration.

Main Results:

  • Recent studies suggest altered small airway function is implicated in CVA.
  • The preservation or loss of the bronchoprotective effect of deep inspiration may be a critical differentiator.
  • These factors may distinguish CVA from typical asthma, methacholine-induced cough, and eosinophilic bronchitis.

Conclusions:

  • Altered small airway function likely plays a significant role in cough variant asthma.
  • The bronchoprotective effect of deep inspiration may be a fundamental pathophysiological difference.
  • Further research is needed to fully elucidate the mechanisms of CVA.