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Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Constitutive and Regulated Gene Expression01:27

Constitutive and Regulated Gene Expression

Gene expression in prokaryotes is governed by constitutive and regulated systems, allowing cells to balance the production of essential proteins with adaptive responses to environmental changes.Constitutive Gene ExpressionConstitutive, or housekeeping, genes are continuously expressed as they encode proteins vital for fundamental cellular processes. These include enzymes for glycolysis, ribosomal components for protein synthesis, and proteins involved in DNA replication. Their constant...
Combinatorial Gene Control02:33

Combinatorial Gene Control

Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
What is Gene Expression?01:42

What is Gene Expression?

Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...

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Related Experiment Video

Updated: May 27, 2026

Pattern-based Search of Epigenomic Data Using GeNemo
06:38

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Published on: October 8, 2017

EpiRegNet: constructing epigenetic regulatory network from high throughput gene expression data for humans.

Lily Yan Wang1, Panwen Wang, Mulin Jun Li

  • 1Department of Biochemistry, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.

Epigenetics
|December 6, 2011
PubMed
Summary

This study introduces EpiRegNet, a web tool for identifying epigenetic factors, like histone modifications, that regulate gene expression changes. It helps build epigenetic regulatory networks and analyze histone modification dynamics across cell types.

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Area of Science:

  • Genomics
  • Epigenetics
  • Bioinformatics

Background:

  • High-throughput profiling (microarray, RNA-seq) identifies thousands of differentially expressed genes.
  • Genetic factors (regulatory motifs) are studied, but epigenetic regulation (histone modifications) is less explored.
  • No existing web server addresses epigenetic factors in gene expression changes.

Purpose of the Study:

  • To develop a web tool for identifying epigenetic factors responsible for gene expression changes.
  • To construct epigenetic regulatory networks and analyze co-localization with transcription factors.
  • To analyze dynamic changes of histone modification marks and their target genes.

Main Methods:

  • The tool accepts categorized genes (up/down-regulated, unchanged).
  • It identifies epigenetic factors and constructs regulatory networks.
  • Performs co-localization analysis with transcription factors from ChIP-seq and predicted data.
  • Integrates experimental and computational data for dynamic histone modification analysis.

Main Results:

  • EpiRegNet identifies epigenetic factors driving gene expression differences.
  • It constructs visualized epigenetic and histone modification regulatory networks.
  • Co-localization analysis with transcription factors is performed.
  • Dynamic gene targeting by histone marks is analyzed across conditions.

Conclusions:

  • EpiRegNet provides a novel platform for studying epigenetic regulation of gene expression.
  • The tool facilitates network construction and analysis of histone modification dynamics.
  • It supports multiple human cell types, custom data uploads, and network visualization.