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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Competing cardiovascular outcomes associated with electrocardiographic left ventricular hypertrophy: the

Chintan S Desai1, Hongyan Ning, Donald M Lloyd-Jones

  • 1Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, 680 N. Lake Shore Drive, Suite 1402, Chicago, IL 60611, USA.

Heart (British Cardiac Society)
|December 6, 2011
PubMed

Insights

Individuals with electrocardiographically determined left ventricular hypertrophy (ECG LVH) face higher risks for cardiovascular disease (CVD) events. Coronary heart disease is most common in men, while heart failure is most common in women with ECG LVH.

Area of Science:

  • Cardiology
  • Public Health
  • Epidemiology

Background:

  • Electrocardiographically determined left ventricular hypertrophy (ECG LVH) is associated with increased risk of cardiovascular disease (CVD).
  • Understanding competing risks for different CVD subtypes and non-CVD death is crucial for individuals with ECG LVH.

Purpose of the Study:

  • To characterize the competing incidences of first CVD events and non-CVD death in individuals with and without ECG LVH.
  • To identify specific CVD subtypes that pose the greatest risk in men and women with ECG LVH.

Main Methods:

  • Utilized data from the Atherosclerosis Risk in Communities (ARIC) Study.
  • Defined ECG LVH using Sokolow-Lyon criteria.
  • Employed competing Cox models to analyze hazards for diverse outcomes within and between groups (ECG LVH vs. no ECG LVH).

Main Results:

  • Men with ECG LVH showed a 29.2% cumulative incidence of first CVD events versus 18.9% in men without ECG LVH over 15 years.
  • Heart failure was the most common first event in women with ECG LVH (10.5%), while coronary heart disease (CHD) was most common in men (15.0%).
  • These associations persisted after adjusting for risk factors like systolic blood pressure.

Conclusions:

  • In middle-aged individuals, ECG LVH predicts higher risks of first CVD events.
  • Coronary heart disease is the primary concern for men with ECG LVH, whereas heart failure is the primary concern for women.
  • Findings may inform targeted preventive strategies for individuals with ECG LVH.
Abstract

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